Mendelian Analysis
Problems:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pedigree and Probabilities:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1. Monohybrid cross (peas)
· Traits vs alleles
· Dominant vs recessive
· Phenotype vs genotype
· Gamete types, zygotes, hybrids
· Punnett square
· Phenotypic ratios vs genotypic ratios
 
2. Monohybrid cross (lilies)
· Data to ratios
· Predict phenotypic ratios
· Testcross
 
3. Dihybrid cross (peas)
· Ratios to Genotypes
· Punnett Square
· Genotypic ratios
· Phenotypic ratios
· Testcross
 
4. Dihybrid cross (aliens)
· Parental phenotypes, F1 ratios; determine parental genotypes
 
5. Monohybrid cross (flies)
· Drosophila nomenclature
· Parental phenotypes, F1 ratios; determine parental genotypes
 
6. Monohybrid,Dihybrid and Trihybrid crosses (hypothetical cows)
· Parental phenotypes, F1 ratios;
· Determine parental genotypes
· Combinatorial probabilities
 
Problems
 
1. Pedigrees
· Pedigree I (dom), II (rare rec), III (common rec.)
· Dominant or recessive
· Assign genotypes
 
2. Probabilities (Dice)
· Probability (e.g. 1/6)
· Sum rule
· Product rule
· Combination of sum and product rule
 
3. Probabilities (M&Ms)
· Sum rule
· Product rule
· Combination of sum and product rule
· "at least one…"
 
4. Probabilities and Pedigrees (PTC)
· Probability offspring dominant trait or recessive trait
· Combination of inheriting trait for particular sex
· Probability of multiple children unaffected
 
5. Probabilities and Pedigrees (rare rec. trait)
· Probability affected offspring
· Dizygotic twins vs monozygotic twins
 
6. Probabilities and Pedigrees (PKU)
· Probability affected offspring
· Probability two out of next five children affected
· Probability of no more than one affected child out of five
 
7. Ascertainment Bias (albinism)
· Real data vs predicted ratios